Endocrine Abstracts

The ability of thyroid hormones to regulate body temperature is well established. While the active hormone T3 can act peripherally to induce thermogenesis in fat and muscle, it also acts centrally in the brain to increase body temperature through the sympathetic nervous system. Most remarkably, recent studies show that T3 treatment in mice causes an elevated body temperature even at 10°C, far below thermoneutrality, suggesting that the T3 effect constitutes pyrexia rather...

The ability of thyroid hormones to regulate body temperature is well established. While the active hormone T3 can act peripherally to induce thermogenesis in fat and muscle, it also acts centrally in the brain to increase body temperature through the sympathetic nervous system. Most remarkably, recent studies show that T3 treatment in mice causes an elevated body temperature even at 10°C, far below thermoneutrality, suggesting that the T3 effect constitutes pyrexia rather...

It is well established that thyroid hormones (TH) possess the ability to regulate body temperature. Thermogenesis can be induced peripherally in fat and muscle, but the active hormone T3 can also act centrally in the brain to raise the body temperature via the sympathetic nervous system. In recent studies, T3 treatment in mice has been shown to elevate the body temperature even far below thermoneutrality. This indicates that the induced hyperthyroidism causes a state of pyrexi...